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Index > Protein center > SLC12A1(Gene name) > Human
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  • SLC12A1 (Gene name),
  • Solute carrier family 12 member 1 (Protein name ),  S12A1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    SLC12A1(NKCC2);
    Protein name:
    Solute carrier family 12 member 1;
    Alternative:
    Kidney-specific Na-K-Cl symporter;Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Electrically silent transporter system. Mediates sodium and chloride reabsorption. Plays a vital role in the regulation of ionic balance and cell volume.
    Subcellular Location:
    Membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    1099
    Sequence:
    50:
    MSLNNSSNVF | LDSVPSNTNR | FQVSVINENH | ESSAAADDNT | DPPHYEETSF | 
    100:
    GDEAQKRLRI | SFRPGNQECY | DNFLQSGETA | KTDASFHAYD | SHTNTYYLQT | 
    150:
    FGHNTMDAVP | KIEYYRNTGS | ISGPKVNRPS | LLEIHEQLAK | NVAVTPSSAD | 
    200:
    RVANGDGIPG | DEQAENKEDD | QAGVVKFGWV | KGVLVRCMLN | IWGVMLFIRL | 
    250:
    SWIVGEAGIG | LGVLIILLST | MVTSITGLST | SAIATNGFVR | GGGAYYLISR | 
    300:
    SLGPEFGGSI | GLIFAFANAV | AVAMYVVGFA | ETVVDLLKES | DSMMVDPTND | 
    350:
    IRIIGSITVV | ILLGISVAGM | EWEAKAQVIL | LVILLIAIAN | FFIGTVIPSN | 
    400:
    NEKKSRGFFN | YQASIFAENF | GPRFTKGEGF | FSVFAIFFPA | ATGILAGANI | 
    450:
    SGDLEDPQDA | IPRGTMLAIF | ITTVAYLGVA | ICVGACVVRD | ATGNMNDTII | 
    500:
    SGMNCNGSAA | CGLGYDFSRC | RHEPCQYGLM | NNFQVMSMVS | GFGPLITAGI | 
    550:
    FSATLSSALA | SLVSAPKVFQ | ALCKDNIYKA | LQFFAKGYGK | NNEPLRGYIL | 
    600:
    TFLIAMAFIL | IAELNTIAPI | ISNFFLASYA | LINFSCFHAS | YAKSPGWRPA | 
    650:
    YGIYNMWVSL | FGAVLCCAVM | FVINWWAAVI | TYVIEFFLYV | YVTCKKPDVN | 
    700:
    WGSSTQALSY | VSALDNALEL | TTVEDHVKNF | RPQCIVLTGG | PMTRPALLDI | 
    750:
    THAFTKNSGL | CICCEVFVGP | RKLCVKEMNS | GMAKKQAWLI | KNKIKAFYAA | 
    800:
    VAADCFRDGV | RSLLQASGLG | RMKPNTLVIG | YKKNWRKAPL | TEIENYVGII | 
    850:
    HDAFDFEIGV | VIVRISQGFD | ISQVLQVQEE | LERLEQERLA | LEATIKDNEC | 
    900:
    EEESGGIRGL | FKKAGKLNIT | KTTPKKDGSI | NTSQSMHVGE | FNQKLVEAST | 
    950:
    QFKKKQEKGT | IDVWWLFDDG | GLTLLIPYIL | TLRKKWKDCK | LRIYVGGKIN | 
    1000:
    RIEEEKIVMA | SLLSKFRIKF | ADIHIIGDIN | IRPNKESWKV | FEEMIEPYRL | 
    1050:
    HESCKDLTTA | EKLKRETPWK | ITDAELEAVK | EKSYRQVRLN | ELLQEHSRAA | 
    1099:
    NLIVLSLPVA | RKGSISDLLY | MAWLEILTKN | LPPVLLVRGN | HKNVLTFYS
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    String:
    MIM:
    Pfam:
    KEGG:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human Solute carrier family 12 member 1
    Cat.:
    E0312h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Solute carrier family 12 member 1
    Cat.:
    E0312r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human Solute carrier family 12 member 1
    MSDS:
    Please sign in first.
    ELISA Kit for Human Solute carrier family 12 member 1
    Cat.:
    E0312m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Solute carrier family 12 member 1
    Cat.:
    U0312m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Solute carrier family 12 member 1
    Cat.:
    U0312r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Solute carrier family 12 member 1
    Cat.:
    U0312h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Solute carrier family 12 member 1
    MSDS:
    Please sign in first.
    Polyclonal Antibody for Human Solute carrier family 12 member 1
    Cat.:
    P0312Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Solute carrier family 12 member 1
    Polyclonal Antibody for Human Solute carrier family 12 member 1
    Cat.:
    P0312Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Solute carrier family 12 member 1
    Cat.:
    P0312Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Solute carrier family 12 member 1
    Monoclonal Antibody for Human Solute carrier family 12 member 1
    Monoclonal Antibody for Human Solute carrier family 12 member 1
    Monoclonal Antibody for Human Solute carrier family 12 member 1
    Protein for Human Solute carrier family 12 member 1
    Protein for Human Solute carrier family 12 member 1
    Protein for Human Solute carrier family 12 member 1
    Protein for Human Solute carrier family 12 member 1

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Bartter's syndrome, hypokalemic alkalosis with hypercalciuria, is caused by mutations in the Na-K-2Cl cotransporter NKCC2."
      Simon D.B. , Karet F.E. , Hamdan J.M. , Di Pietro A. , Sanjad S.A. , Lifton R.P.
      Nat. Genet.13:183-188(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM F);VARIANTS BS1 PHE-272 AND ASN-648;VARIANT ALA-958;ALTERNATIVE SPLICING
    2. 2.
      "Molecular cloning and characterization of NKCC2A in non-renal tissues."
      Di Fulvio M. , Garzon-Muvdi T. , Alvarez-Leefmans F.J.
      Submitted (2007-11) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A);VARIANT ALA-958
      tissue: Spinal ganglion.
    3. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ENZYME REGULATION
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